A potent peptide inhibitor of α-synuclein aggregation.
Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation. Cheruvara H, Allen-Baume VL, Kad NM, Mason JM., J. Biol. Chem., 2015, First published on-line: January 23, 2015. DOI: 10.1074/jbc.M114.620484 Aggregation of α-synuclein (α-syn) into toxic fibrils is a pathogenic hallmark of Parkinson’s disease (PD). Studies have largely focused on residues 71-82, yet…