Dipeptide chemosensor for silver ions and silver nanoparticles
Highly Sensitive Ratiometric Fluorescent Chemosensor for Silver Ion and Silver Nanoparticles in Aqueous Solution
S. Jang, P. Thirupathi, L. N. Neupane, J. Seong, H. Lee, W. I. Lee, and K.-H. Lee, Org. Lett., Article ASAP
DOI: 10.1021/ol301991h
Publication Date (Web): September 5, 2012
Copyright © 2012 American Chemical Society
A pyrene derivative chemosensor (Pyr-WH) based on a dipeptide shows a highly sensitive ratiometric response to Ag(I) as well as silver nanoparticles in aqueous solution at physiological pH. Pyr-WH penetrated live HeLa cells and exhibits a ratiometric response to intracellular Ag(I). The binding mode of Pyr-WH with Ag(I) was characterized based on fluorescence changes in different pH, NMR, and ESI mass spectrometer experiments.
Keyword: Peptide APIs
