Identification of the Minimum Peptide from Mouse Myostatin Prodo
Identification of the Minimum Peptide from Mouse Myostatin Prodomain for Human Myostatin Inhibition Kentaro Takayama, Yuri Noguchi, Shin Aoki, Shota Takayama, Momoko Yoshida, Tomo Asari, Fumika Yakushiji, Shin-ichiro Nishimatsu, Yutaka Ohsawa, Fumiko Itoh, Yoichi Negishi, Yoshihide Sunada, and Yoshio Hayashi, J. Med. Chem., 2015, 58, 1544-1549. Myostatin, an endogenous negative regulator of skeletal muscle mass, is a therapeutic target for muscle atrophic disorders. Here, we identified minimum peptides 2 and 7 to effectively inhibit myostatin…